Balapiravir

• CAT Number: I004595
• CAS Number: 690270-29-2
• Molecular Formula: C21H30N6O8
• Molecular Weight: 494.5
• Purity: 95%
• Synonyms: [(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-2-azido-3,4-bis(2-methylpropanoyloxy)oxolan-2-yl]methyl 2-methylpropanoate; R-1626; Ro4588161; R1626
• Target: HCV Protease
• Solubility: DMSO: ≥ 100 mg/mL
• Appearance: Solid powder
• Storage: Store at -20°C
• IUPAC Name: [(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-2-azido-3,4-bis(2-methylpropanoyloxy)oxolan-2-yl]methyl 2-methylpropanoate
• InChI: InChI=1S/C21H30N6O8/c1-10(2)17(28)32-9-21(25-26-23)15(34-19(30)12(5)6)14(33-18(29)11(3)4)16(35-21)27-8-7-13(22)24-20(27)31/h7-8,10-12,14-16H,9H2,1-6H3,(H2,22,24,31)/t14-,15+,16-,21-/m1/s1
• InChIKey: VKXWOLCNTHXCLF-DXEZIKHYSA-N
• SMILES: CC(C)C(=O)OCC1(C(C(C(O1)N2C=CC(=NC2=O)N)OC(=O)C(C)C)OC(=O)C(C)C)N=[N+]=[N-]

Balapiravir(CAT: I004595), also known as R-1626, is an antiviral drug that was developed for the treatment of hepatitis C virus (HCV) infection. It is a prodrug of a nucleoside analog that works by inhibiting the RNA-dependent RNA polymerase enzyme that is required for HCV replication. Balapiravir has been shown to be effective against several genotypes of HCV in preclinical studies and early clinical trials. However, later-stage clinical trials showed that it had limited efficacy and significant adverse effects, leading to its discontinuation as a potential treatment for HCV. Despite its failure in the treatment of HCV, balapiravir remains an important compound in the development of new antiviral drugs, as it helped to identify key targets and mechanisms for the development of effective treatments for viral infections.

Overview of Clinical Research

Originator Novartis
Developer Roche
Class Antivirals; Pyrimidine nucleosides; Small molecules
Mechanism of Action Hepatitis C virus NS 5 protein inhibitors
Orphan Drug Status No

Reference

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