For research use only. Not for therapeutic Use.
Balicatib（Cat No.:I003294）is an investigational drug that acts as a selective inhibitor of cathepsin K, a cysteine protease enzyme involved in bone resorption. By inhibiting cathepsin K, balicatib aims to reduce the breakdown of bone tissue, which is a key factor in conditions like osteoporosis, where excessive bone loss occurs. Balicatib has been studied for its potential in treating osteoporotic fractures and other bone-related disorders. Although it showed promise in clinical trials, its development was halted due to concerns about safety, particularly with long-term use and effects on the skin and other tissues.
| Catalog Number | I003294 |
| CAS Number | 354813-19-7 |
| Synonyms | AAE581 |
| Molecular Formula | C₂₃H₃₃N₅O₂ |
| Purity | ≥95% |
| Target | Cathepsin |
| Solubility | DMSO: ≥ 46 mg/mL |
| Storage | -20°C |
| IUPAC Name | N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide |
| InChI | InChI=1S/C23H33N5O2/c1-2-14-27-15-17-28(18-16-27)20-8-6-19(7-9-20)21(29)26-23(10-4-3-5-11-23)22(30)25-13-12-24/h6-9H,2-5,10-11,13-18H2,1H3,(H,25,30)(H,26,29) |
| InChIKey | LLCRBOWRJOUJAE-UHFFFAOYSA-N |
| SMILES | CCCN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3(CCCCC3)C(=O)NCC#N |
| Reference | </br>1:Morphea-like skin reactions in patients treated with the cathepsin K inhibitor balicatib. Rünger TM, Adami S, Benhamou CL, Czerwiński E, Farrerons J, Kendler DL, Mindeholm L, Realdi G, Roux C, Smith V.J Am Acad Dermatol. 2012 Mar;66(3):e89-96. doi: 10.1016/j.jaad.2010.11.033. Epub 2011 May 14. PMID: 21571394 </br>2:Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys. Jerome C, Missbach M, Gamse R.Osteoporos Int. 2012 Jan;23(1):339-49. doi: 10.1007/s00198-011-1593-2. Epub 2011 Mar 5. PMID: 21380636 </br>3:Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys. Jerome C, Missbach M, Gamse R.Osteoporos Int. 2011 Dec;22(12):3001-11. doi: 10.1007/s00198-011-1529-x. Epub 2011 Feb 10. PMID: 21308366 </br>4:Drug-induced morphea: report of a case induced by balicatib and review of the literature. Peroni A, Zini A, Braga V, Colato C, Adami S, Girolomoni G.J Am Acad Dermatol. 2008 Jul;59(1):125-9. doi: 10.1016/j.jaad.2008.03.009. Epub 2008 Apr 14. Review. PMID: 18410981 |
