For research use only. Not for therapeutic Use.
BAM15 is a potent and selective mitochondrial uncoupler or protonophore. Chemical mitochondrial uncouplers are lipophilic weak acids that transport protons into the mitochondrial matrix via a pathway that is independent of ATP synthase, thereby uncoupling nutrient oxidation from ATP production. These uncouplers have potential for the treatment of diseases such as obesity, Parkinson’s disease, and aging.
| Catalog Number | I002807 |
| CAS Number | 210302-17-3 |
| Synonyms | BAM15; BAM-15; BAM 15.;N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine |
| Molecular Formula | C16H10F2N6O |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | -20°C |
| InChIKey | OEGJBRZAJRPPHL-UHFFFAOYSA-N |
| SMILES | FC1=CC=CC=C1NC2=NC3=NON=C3N=C2NC4=C(F)C=CC=C4 |
| Reference | </br>1: Shukla S, Lee JS, Park HK, Yoo JA, Hong SY, Kim JK, Kim M. Effect of Novel</br> Starter Culture on Reduction of Biogenic Amines, Quality Improvement, and Sensory</br> Properties of Doenjang, a Traditional Korean Soybean Fermented Sauce Variety. J</br> Food Sci. 2015 Aug;80(8):M1794-803. doi: 10.1111/1750-3841.12942. Epub 2015 Jul</br> 3. PubMed PMID: 26147854.</br>2: Kenwood BM, Calderone JA, Taddeo EP, Hoehn KL, Santos WL. Structure-activity</br> relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg Med</br> Chem Lett. 2015 Nov 1;25(21):4858-61. doi: 10.1016/j.bmcl.2015.06.040. Epub 2015 </br> Jun 16. PubMed PMID: 26119501.</br>3: Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA,</br> Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L,</br> Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, </br> Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL. Identification of a novel</br> mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metab. </br> 2013 Nov 28;3(2):114-23. doi: 10.1016/j.molmet.2013.11.005. eCollection 2014 Apr.</br> PubMed PMID: 24634817; PubMed Central PMCID: PMC3953706.</br>4: Kunapuli P, Lee S, Zheng W, Alberts M, Kornienko O, Mull R, Kreamer A, Hwang</br> JI, Simon MI, Strulovici B. Identification of small molecule antagonists of the</br> human mas-related gene-X1 receptor. Anal Biochem. 2006 Apr 1;351(1):50-61. Epub</br> 2006 Feb 3. PubMed PMID: 16510108.</br></br> |
