BAM7

• CAT Number: I003191
• CAS Number: 331244-89-4
• Molecular Formula: C21H19N5O2S
• Molecular Weight: 405.5
• Purity: ≥95%
• Synonyms: (4E)-4-[(2-ethoxyphenyl)hydrazinylidene]-5-methyl-2-(4-phenyl-1,3-thiazol-2-yl)pyrazol-3-one
• Target: Bcl-2 Family
• Solubility: 10 mM in DMSO (warmed)
• Storage: Store at -20°C
• IC50: 3.3 uM(EC50) [1]
• IUPAC Name: 4-[(2-ethoxyphenyl)diazenyl]-5-methyl-2-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazol-3-one
• InChI: InChI=1S/C21H19N5O2S/c1-3-28-18-12-8-7-11-16(18)23-24-19-14(2)25-26(20(19)27)21-22-17(13-29-21)15-9-5-4-6-10-15/h4-13,25H,3H2,1-2H3
• InChIKey: WRLVHADVOGFZOZ-UHFFFAOYSA-N
• SMILES: CCOC1=CC=CC=C1N=NC2=C(NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C

BAM7（Cat No.:I003191）, is a compound used in tumor therapy. It functions as an activator of the pro-apoptotic protein BAX, promoting programmed cell death in cancer cells. BAM7 directly and selectively binds to BAX, triggering its apoptotic activity. With a potency indicated by a <BEC50 value of 3.3 μM, BAM7 shows potential as an effective agent for inducing apoptosis and combating tumors in therapeutic applications.

Reference

[1]. Gavathiotis E, Reyna DE, Bellairs JA, Direct and selective small-molecule activation of proapoptotic BAX. Nat Chem Biol. 2012 Jul;8(7):639-45.