BAMB-4

• CAT Number: I005337
• CAS Number: 891025-25-5
• Molecular Formula: C15H12N2O2
• Molecular Weight: 252.27
• Purity: ≥95%
• Target: Phosphatase
• Solubility: DMSO: ≥ 40 mg/mL
• Storage: Store at -20C
• IC50: 37 uM
• IUPAC Name: N-(1,2-benzoxazol-3-yl)-4-methylbenzamide
• InChI: InChI=1S/C15H12N2O2/c1-10-6-8-11(9-7-10)15(18)16-14-12-4-2-3-5-13(12)19-17-14/h2-9H,1H3,(H,16,17,18)
• InChIKey: IEPCQLHHUYRTEY-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)C(=O)NC2=NOC3=CC=CC=C32

BAMB-4 (CAT: I005337) is a novel, membrane-permeable inhibitor targeting inositol-1,4,5-trisphosphate-3-kinase A (ITPKA), with an IC50 of 37 µM in ADP-Glo assays. By inhibiting ITPKA, it disrupts the phosphorylation of inositol-1,4,5-trisphosphate, a critical regulator of intracellular calcium signaling and neuronal activity. BAMB-4 is particularly relevant in neurobiology and cancer research, where ITPKA is implicated in processes like synaptic plasticity and tumor metastasis. Its high specificity and permeability make BAMB-4 an essential tool for studying ITPKA’s biological roles and exploring therapeutic applications in diseases linked to dysregulated calcium signaling or ITPKA overexpression.