For research use only. Not for therapeutic Use.
BAR-501 (Cat.No:I003944) is a selective GPBAR1 agonist devoid of any FXR agonistic activity. BAR501 effectively reduced hepatic perfusion pressure and counteracted the vasoconstriction activity of norepinephrine. BAR501 rescues from endothelial dysfunction in rodent model.
| Catalog Number | I003944 |
| CAS Number | 1632118-69-4 |
| Synonyms | BAR-501; BAR 501; BAR501.;(3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol |
| Molecular Formula | C26H46O3 |
| Purity | ≥95% |
| Target | G protein-coupled Bile Acid Receptor 1 |
| Solubility | Soluble in DMSO |
| Storage | store at -20°C |
| IUPAC Name | (3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-[(2R)-5-hydroxypentan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol |
| InChI | InChI=1S/C26H46O3/c1-5-18-22-15-17(28)10-12-26(22,4)21-11-13-25(3)19(16(2)7-6-14-27)8-9-20(25)23(21)24(18)29/h16-24,27-29H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21+,22+,23+,24+,25-,26-/m1/s1 |
| InChIKey | DQBAHTQWQZRMFH-CRPAWOMZSA-N |
| SMILES | C[C@H](CCCO)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C |
| Reference | </br>1: Renga B, Cipriani S, Carino A, Simonetti M, Zampella A, Fiorucci S. Reversal</br> of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a</br> AKT/FOXOA1 Dependent Regulation of H2S Generation and Endot |
