For research use only. Not for therapeutic Use.
Barbadin (Cat.No:I018157) is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors.
| Catalog Number | I018157 |
| CAS Number | 356568-70-2 |
| Molecular Formula | C₁₉H₁₅N₃OS |
| Purity | ≥95% |
| Target | GPCR/G Protein |
| IUPAC Name | 3-amino-5-(4-benzylphenyl)thieno[2,3-d]pyrimidin-4-one |
| InChI | InChI=1S/C19H15N3OS/c20-22-12-21-18-17(19(22)23)16(11-24-18)15-8-6-14(7-9-15)10-13-4-2-1-3-5-13/h1-9,11-12H,10,20H2 |
| InChIKey | OCBXPCSXEQQADU-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)CC2=CC=C(C=C2)C3=CSC4=C3C(=O)N(C=N4)N |
| Reference | [1]. Beautrait A, et al. A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054. |
