Barnidipine

For research use only. Not for therapeutic Use.

  • CAT Number: I018513
  • CAS Number: 104713-75-9
  • Molecular Formula: C₂₇H₂₉N₃O₆
  • Molecular Weight: 491.54
  • Purity: ≥95%
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Barnidipine (Mepirodipine) (Cat.No:I018513) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors. Barnidipine (Mepirodipine) is an antihypertensive drug and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action.


Catalog Number I018513
CAS Number 104713-75-9
Molecular Formula C₂₇H₂₉N₃O₆
Purity ≥95%
IUPAC Name 5-O-[(3S)-1-benzylpyrrolidin-3-yl] 3-O-methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChI InChI=1S/C27H29N3O6/c1-17-23(26(31)35-3)25(20-10-7-11-21(14-20)30(33)34)24(18(2)28-17)27(32)36-22-12-13-29(16-22)15-19-8-5-4-6-9-19/h4-11,14,22,25,28H,12-13,15-16H2,1-3H3/t22-,25-/m0/s1
InChIKey VXMOONUMYLCFJD-DHLKQENFSA-N
SMILES CC1=C([C@@H](C(=C(N1)C)C(=O)O[C@H]2CCN(C2)CC3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC
Reference

[1]. van Zwieten PA, et al. Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist. Blood Press Suppl. 1998;1:5-8<br>[2]. Malhotra HS, et al. Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8.

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