Batatasin III

• CAT Number: R066445
• CAS Number: 56684-87-8
• Molecular Formula: C15H16O3
• Molecular Weight: 244.29
• Purity: ≥95%
• Synonyms: 3-[2-(3-hydroxyphenyl)ethyl]-5-methoxyphenol
• InChI: InChI=1S/C15H16O3/c1-18-15-9-12(8-14(17)10-15)6-5-11-3-2-4-13(16)7-11/h2-4,7-10,16-17H,5-6H2,1H3
• InChIKey: VYQXIUVIYICVCM-UHFFFAOYSA-N
• SMILES: COC1=CC(=CC(=C1)O)CCC2=CC(=CC=C2)O

Batatasin III, a stilbenoid, inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition (EMT) and FAK-AKT signals. Batatasin III has anti-cancer activities[1].
Batatasin III (25-100 μM; 48 h) exhibits anti-proliferative activity in H460 cells. Batatasin III at concentrations lower than 100 μM has no cytotoxic effects[1].
Batatasin III significantly suppresses EMT indicated by the decrease of N-cadherin and Vimentin, and up-regulation of E-cadherin[1].

Reference

[1]. Tatchakorn Pinkhien, et al. Batatasin III Inhibits Migration of Human Lung Cancer Cells by Suppressing Epithelial to Mesenchymal Transition and FAK-AKT Signals. Anticancer Res. 2017 Nov;37(11):6281-6289.
 [Content Brief]