For research use only. Not for therapeutic Use.
Bax channel blockers（Cat No.:I010517）are compounds that inhibit the activity of Bax, a pro-apoptotic protein involved in the mitochondrial pathway of cell death. Bax plays a critical role in the initiation of apoptosis (programmed cell death) by promoting mitochondrial membrane permeabilization, leading to the release of cytochrome c and activation of caspases. By blocking Bax, these compounds are studied for their potential to prevent unwanted cell death, particularly in neurodegenerative diseases, ischemic injury, and other conditions where cell survival is compromised. Bax channel blockers may also offer a therapeutic approach for conditions involving excessive apoptosis, like certain cancers.
| Catalog Number | I010517 |
| CAS Number | 329349-20-4 |
| Synonyms | 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride |
| Molecular Formula | C19H23Br2Cl2N3O |
| Purity | ≥95% |
| Solubility | Soluble to 5 mM in water and to 100 mM in DMSO |
| Storage | Desiccate at RT |
| IUPAC Name | 1-(3,6-dibromocarbazol-9-yl)-3-piperazin-1-ylpropan-2-ol;dihydrochloride |
| InChI | InChI=1S/C19H21Br2N3O.2ClH/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)24(18)12-15(25)11-23-7-5-22-6-8-23;;/h1-4,9-10,15,22,25H,5-8,11-12H2;2*1H |
| InChIKey | HWFKCAFKXZFOQT-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1)CC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O.Cl.Cl |
