Bax inhibitor peptide V5

• CAT Number: I004164
• CAS Number: 579492-81-2
• Molecular Formula: C27H50N6O6S
• Molecular Weight: 586.79
• Purity: ≥95%
• Synonyms: (S)-6-amino-2-((Z)-((S)-2-((Z)-((S)-2-((Z)-(((S)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)(hydroxy)methylene)amino)-1-hydroxy-4-(methylthio)butylidene)amino)-1-hydroxy-4-methylpentylidene)amino)hexanoic acid
• Target: Bcl-2 Family
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: Desiccate at -20°C

Bax Inhibitor Peptide V5(CAT: I004164), also known as Bax Inhibitor V5 or BIP-V5, is a synthetic peptide designed to inhibit the activity of Bax, a pro-apoptotic protein involved in the regulation of programmed cell death. Bax Inhibitor Peptide V5 works by blocking the interaction between Bax and its target molecules, thereby preventing Bax-mediated apoptosis. It has been used as a research tool to study the role of Bax in various cellular processes and to investigate potential therapeutic strategies targeting Bax-mediated apoptosis.

Reference

[1]. Sawada M, et al. Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70. Nat Cell Biol. 2003 Apr;5(4):352-7.
[2]. Rivas-Carrillo JD, et al. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. Diabetes. 2007 May;56(5):1259-67. Epub 2007 Feb 7.