For research use only. Not for therapeutic Use.
BAY 11-7085, a soluble inhibitor of NK-kappaB activation, has been shown to inhibit cell proliferation and induce apoptosis of a variety of cells. BAY 11-7085 induces apoptosis of ECSCs by suppressing antiapoptotic proteins, and that caspase-3-, -8-, and -9-mediated cascades are involved in this mechanism. BAY 11-7085 could be used as a therapeutic agent for the treatment of endometriosis. BAY 11-7085 protects against gut ischemia-reperfusion injury.
| Catalog Number | R060709 |
| CAS Number | 196309-76-9 |
| Synonyms | (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile; (E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile; BAY 117083 |
| Molecular Formula | C13H15NO2S |
| Purity | ≥95% |
| Target | Apoptosis |
| Solubility | >12.5mg/mL in DMSO |
| Storage | Store at -20 C |
| InChIKey | VHKZGNPOHPFPER-ONNFQVAWSA-N |
| Reference | </br>1:BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death. Relic B, Charlier E, Deroyer C, Malaise O, Neuville S, Desoroux A, Gillet P, de Seny D, Malaise MG.Oncotarget. 2016 Apr 26;7(17):23370-82. doi: 10.18632/oncotarget.8042. PMID: 26993765 Free PMC Article</br>2:Cytotoxicity of NF-kappaB inhibitors Bay 11-7085 and caffeic acid phenethyl ester to Ramos and other human B-lymphoma cell lines. Berger N, Ben Bassat H, Klein BY, Laskov R.Exp Hematol. 2007 Oct;35(10):1495-509. PMID: 17889719 </br>3:Application of the nuclear factor-kappaB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study. Nasu K, Nishida M, Ueda T, Yuge A, Takai N, Narahara H.Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E16-23. Epub 2006 Aug 8. PMID: 16896168 Free Article</br>4:Peroxisome proliferator-activated receptor-gamma1 is dephosphorylated and degraded during BAY 11-7085-induced synovial fibroblast apoptosis. Relic B, Benoit V, Franchimont N, Kaiser MJ, Hauzeur JP, Gillet P, Merville MP, Bours V, Malaise MG.J Biol Chem. 2006 Aug 11;281(32):22597-604. Epub 2006 Jun 9. PMID: 16766531 Free Article</br>5:NF-kappaB signaling blockade by Bay 11-7085 during early cardiac morphogenesis induces alterations of the outflow tract in chicken heart. Hernández-Gutierrez S, García-Peláez I, Zentella-Dehesa A, Ramos-Kuri M, Hernández-Franco P, Hernández-Sánchez F, Rojas E.Apoptosis. 2006 Jul;11(7):1101-9. PMID: 16699956 </br>6:Induction of apoptosis in p53-deficient L1210 cells by an I-kappa-B-alpha-inhibitor (Bay 11-7085) via a NF-kappa-B-independent mechanism. Cory AH, Cory JG.Adv Enzyme Regul. 2005;45:85-93. Epub 2005 Aug 29. PMID: 16129475 </br>7:15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts. Relic B, Benoit V, Franchimont N, Ribbens C, Kaiser MJ, Gillet P, Merville MP, Bours V, Malaise MG.J Biol Chem. 2004 May 21;279(21):22399-403. Epub 2004 Mar 5. PMID: 15004016 Free Article</br>8:Delayed administration of alpha-melanocyte-stimulating hormone or combined therapy with BAY 11-7085 protects against gut ischemia-reperfusion injury. Zou L, Sato N, Attuwaybi BO, Kone BC.Shock. 2003 Nov;20(5):469-75. PMID: 14560113 |
