For research use only. Not for therapeutic Use.
(-)-BAY-1251152（Cat No.:I019684）is a selective inhibitor of the protein kinase CK2, which is implicated in various cellular processes, including cell proliferation and survival. This compound has shown promise in preclinical studies for its potential to induce apoptosis and inhibit tumor growth in several cancer types. By targeting CK2, (-)-BAY-1251152 disrupts signaling pathways that are often dysregulated in malignancies, providing a novel therapeutic approach. Ongoing research aims to evaluate its efficacy and safety in clinical trials, exploring its potential use in combination therapies to enhance treatment outcomes in oncology.
| Catalog Number | I019684 |
| CAS Number | 1610358-59-2 |
| Molecular Formula | C₁₉H₁₈F₂N₄O₂S |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(methylsulfonimidoyl)methyl]pyridin-2-yl]pyridin-2-amine |
| InChI | InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25) |
| InChIKey | YZCUMZWULWOUMD-UHFFFAOYSA-N |
| SMILES | COC1=C(C=CC(=C1)F)C2=CC(=NC=C2F)NC3=NC=CC(=C3)CS(=N)(=O)C |
| Reference | [1]. Luecking, et al. Identification of potent and highly selective PTEFb inhibitor BAY 1251152 for the treatment of cancer: from p.o. to i.v. application via scaffold hops. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 984. doi:10.1158/1538-7445.AM2017-984 |
