For research use only. Not for therapeutic Use.
BAY 2476568 is a potent and selective EGFR inhibitor, with IC50s of < 0.2 nM for wild-type EGFR and several mutations (EGFRR ex20insSVD, EGFRR ex20insASV, EGFRR ex20insNPG)[1].
| Catalog Number | I044534 |
| CAS Number | 2311901-93-4 |
| Synonyms | 3-(3-fluoro-2-methoxyanilino)-2-[3-(2-methoxy-2-methylpropoxy)pyridin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one |
| Molecular Formula | C24H27FN4O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H27FN4O4/c1-24(2,32-4)13-33-18-12-26-10-8-14(18)20-21(19-16(28-20)9-11-27-23(19)30)29-17-7-5-6-15(25)22(17)31-3/h5-8,10,12,28-29H,9,11,13H2,1-4H3,(H,27,30) |
| InChIKey | ZOEVXMKZJWZLFX-UHFFFAOYSA-N |
| SMILES | CC(C)(COC1=C(C=CN=C1)C2=C(C3=C(N2)CCNC3=O)NC4=C(C(=CC=C4)F)OC)OC |
| Reference | [1]. Stephan Siegel, et al. 4h-pyrrolo[3,2-c]pyridin-4-one derivatives. WO2019081486A1. |
