BAY-390

• CAT Number: I042641
• CAS Number: 2741956-55-6
• Molecular Formula: C13H15F4NO
• Molecular Weight: 277.26
• Purity: ≥95%
• Synonyms: (1R,2R)-2-(4-fluoroanilino)-1-(trifluoromethyl)cyclohexan-1-ol
• InChI: InChI=1S/C13H15F4NO/c14-9-4-6-10(7-5-9)18-11-3-1-2-8-12(11,19)13(15,16)17/h4-7,11,18-19H,1-3,8H2/t11-,12-/m1/s1
• InChIKey: IESAJAZKMLPVIB-VXGBXAGGSA-N
• SMILES: C1CCC(C(C1)NC2=CC=C(C=C2)F)(C(F)(F)F)O

BAY-390 is a selective, across species active and brain penetrating TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50s of 16, 82, 63 and 35 nM, respectively. BAY-390 can be used for the research of inflammation[1].
BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50s of 16, 82, 63 and 35 nM, respectively[1].
BAY-390 inhibits mTRPA1, gpTRPA1, dogTRPA1 and monkeyTRPA1 with IC50s of 73, 68, 81 and 19 nM, respectively[1].
BAY-390 (30 and 90 mg/kg; p.o.; BID for 10 days) effects the neuropathic pain in vivo[1].
BAY-390 reduces visceral pain in rat cyclophosphamide induced cystitis models[1].
BAY-390 shows efficacy in inflammatory pain and neurogenic inflammation models[1].

Reference

[1].