BAY-524

• CAT Number: I004006
• CAS Number: 1445830-39-6
• Molecular Formula: C24H24F2N6O3
• Molecular Weight: 482.48
• Purity: ≥95%
• Synonyms: 2-[1-[(4-ethoxy-2,6-difluorophenyl)methyl]-5-methoxy-4-methylpyrazol-3-yl]-5-methoxy-N-pyridin-4-ylpyrimidin-4-amine
• InChI: InChI=1S/C24H24F2N6O3/c1-5-35-16-10-18(25)17(19(26)11-16)13-32-24(34-4)14(2)21(31-32)23-28-12-20(33-3)22(30-23)29-15-6-8-27-9-7-15/h6-12H,5,13H2,1-4H3,(H,27,28,29,30)
• InChIKey: LMRCQVHTZUUHFN-UHFFFAOYSA-N
• SMILES: CCOC1=CC(=C(C(=C1)F)CN2C(=C(C(=N2)C3=NC=C(C(=N3)NC4=CC=NC=C4)OC)C)OC)F

BAY-524 is a potent Bub1 kinase inhibitor. BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM. BAY-524 can be used for the research of anti-cancer in combination with other agents[1].
BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM[1].
BAY-524 (7-10 μM or 0-30 μM; 14 h or 1 h) specifically inhibit Bub1 kinase[1].
BAY-524 (7 μM , 12 h or 7 μM, 12 μM, 3 h) affects Sgo1 and Sgo2 localization and chromatid cohesion in cells[1].
BAY-524 (7 μM, 10 μM) affects localization and activity of the CPC[1].
BAY-524 (7 μM, 2 h) exerts additive effect on centromere association of CPC[1].
BAY-524 (7 μM, 48 h) marginally affects SAC signaling[1].
BAY-524 (7 μM, 10 μM) sensitizes cells to low doses of paclitaxel[1].

Reference

[1]. Baron AP, et al. Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524. Elife. 2016 Feb 17;5. pii: e12187.
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