For research use only. Not for therapeutic Use.
BAY-6035 is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC50 of 88 nM[1].
BAY-6035 inhibits in vitro methylation of MEKK2 peptide with an IC50 of 88 nM and has more than 100-fold selectivity over other histone methyltransferases[1].
BAY-6035 inhibits the methylation of MEKK2 in cells with an IC50 of 70 nM[1].
| Catalog Number | I015061 |
| CAS Number | 2247890-13-5 |
| Synonyms | (2S)-1-(3-azabicyclo[3.1.0]hexane-3-carbonyl)-N-(2-cyclopropylethyl)-2-methyl-4-oxo-3,5-dihydro-2H-1,5-benzodiazepine-7-carboxamide |
| Molecular Formula | C22H28N4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H28N4O3/c1-13-8-20(27)24-18-10-15(21(28)23-7-6-14-2-3-14)4-5-19(18)26(13)22(29)25-11-16-9-17(16)12-25/h4-5,10,13-14,16-17H,2-3,6-9,11-12H2,1H3,(H,23,28)(H,24,27)/t13-,16?,17?/m0/s1 |
| InChIKey | CKFRXCBNKKOFGO-IGEOTXOUSA-N |
| SMILES | CC1CC(=O)NC2=C(N1C(=O)N3CC4CC4C3)C=CC(=C2)C(=O)NCCC5CC5 |
| Reference | [1]. Edoardo F, et, al. Small-molecule inhibitors of lysine methyltransferases SMYD2 and SMYD3: current trends. Future Med Chem. 2019 Apr; 11(8): 901-921. |
