For research use only. Not for therapeutic Use.
BAY 61-3606 dihydrochloride(Cat No.:I004446)is a selective small-molecule inhibitor of spleen tyrosine kinase (Syk), a key regulator of immune cell signaling and inflammatory responses. By inhibiting Syk, BAY 61-3606 dihydrochloride blocks the activation of downstream pathways involved in B-cell receptor signaling and Fc receptor-mediated responses, making it a valuable compound for research in autoimmune diseases, inflammation, and allergic reactions. Its selective inhibition of Syk has potential therapeutic implications in conditions like rheumatoid arthritis, asthma, and certain cancers, particularly those involving aberrant immune cell signaling.
Catalog Number | I004446 |
CAS Number | 648903-57-5 |
Synonyms | 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide;dihydrochloride |
Molecular Formula | C20H20Cl2N6O3 |
Purity | ≥95% |
Target | Syk; Apoptosis |
Solubility | DMSO: ≥ 4.6 mg/mL |
Storage | Store at -20°C |
IC50 | 7.5 nM (Ki) [1] |
IUPAC Name | 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide;dihydrochloride |
InChI | InChI=1S/C20H18N6O3.2ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25);2*1H |
InChIKey | SPMFEULFGGPQLN-UHFFFAOYSA-N |
SMILES | COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC.Cl.Cl |
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