BAY 61-3606 dihydrochloride

• CAT Number: I004446
• CAS Number: 648903-57-5
• Molecular Formula: C20H20Cl2N6O3
• Molecular Weight: 463.32
• Purity: ≥95%
• Synonyms: 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide;dihydrochloride
• Target: Syk; Apoptosis
• Solubility: DMSO: ≥ 4.6 mg/mL
• Storage: Store at -20°C
• IC50: 7.5 nM (Ki) [1]
• InChI: InChI=1S/C20H18N6O3.2ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25);2*1H
• InChIKey: SPMFEULFGGPQLN-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC.Cl.Cl

BAY 61-3606 dihydrochloride（Cat No.:I004446）is a selective small-molecule inhibitor of spleen tyrosine kinase (Syk), a key regulator of immune cell signaling and inflammatory responses. By inhibiting Syk, BAY 61-3606 dihydrochloride blocks the activation of downstream pathways involved in B-cell receptor signaling and Fc receptor-mediated responses, making it a valuable compound for research in autoimmune diseases, inflammation, and allergic reactions. Its selective inhibition of Syk has potential therapeutic implications in conditions like rheumatoid arthritis, asthma, and certain cancers, particularly those involving aberrant immune cell signaling.

Reference

[1]. Yamamoto N, et al. The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J Pharmacol Exp Ther. 2003 Sep;306(3):1174-81.
[2]. Lau KS, et al. BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. PLoS One. 2012;7(7):e41343.