Bay 61-3606 Hydrochloride

• CAT Number: I004726
• CAS Number: 732983-37-8
• Molecular Formula: C₂₀H₁₈N₆O₃.HCl
• Molecular Weight: 426.86
• Purity: ≥95%
• Synonyms: 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide
• Target: Apoptosis
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 7.5 nM (Ki)
• InChI: InChI=1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25)
• InChIKey: JWQOJVOKBAAAAR-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC

Bay 61-3606 Hydrochloride（Cat No.:I004726）is a potent and selective inhibitor of Syk (spleen tyrosine kinase), an enzyme involved in immune cell signaling pathways, particularly in B-cell receptor (BCR) and Fc receptor signaling. By inhibiting Syk, Bay 61-3606 disrupts key pathways responsible for immune cell activation, proliferation, and inflammatory response. It has applications in researching autoimmune disorders, allergies, and hematological malignancies where Syk plays a critical role. Bay 61-3606 is a valuable tool for studying immune signaling mechanisms and the potential therapeutic targeting of Syk in inflammatory and immune-mediated diseases.

Reference

[1]. Yamamoto N, et al. The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J Pharmacol Exp Ther. 2003 Sep;306(3):1174-81.

[2]. Lau KS, et al. BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. PLoS One. 2012;7(7):e41343.