Bay-K-8644 (S)-(-)-

• CAT Number: I005729
• CAS Number: 98625-26-4
• Molecular Formula: C16H15F3N2O4
• Molecular Weight: 356.3
• Purity: ≥95%
• Synonyms: (S)-methyl 2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylate
• Target: Calcium Channel
• Solubility: 10 mM in DMSO
• Storage: 2-8°C
• IUPAC Name: methyl (4S)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
• InChI: InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1
• InChIKey: ZFLWDHHVRRZMEI-ZDUSSCGKSA-N
• SMILES: CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC

(S)-(-)-Bay-K-8644（Cat No.:I005729） is a specific agonist of L-type calcium channels. It activates Ba2+ currents (IBa) with a potent effect, exhibiting an EC50 (half-maximal effective concentration) of 32 nM. By binding and activating L-type calcium channels, (S)-(-)-Bay-K-8644 enhances calcium influx into cells, leading to various physiological responses. This compound’s ability to modulate L-type calcium channels makes it a valuable tool in studying calcium channel function and investigating the role of calcium signaling in cellular processes and disease states.

Reference

[1]. Rampe D, et al. Functional interactions between two Ca2+ channel activators, (S)-Bay K 8644 and FPL 64176, in smooth muscle. Mol Pharmacol. 1992 Apr;41(4):599-602. 


[2]. Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15. 


[3]. Rump AF, et al. Influence of (-)-S-Bay K 8644, (+/-)-Bay W 5035 and (+/-)-Bay T 5006 on hemodynamics and FITC-dextran 3 elution kinetics in isolated rat hearts. Gen Pharmacol. 1993 May;24(3):631-6.