For research use only. Not for therapeutic Use.
BAY-Y 3118（Cat No.:I013378）is a synthetic fluoroquinolone antibiotic with potent activity against gram-positive and gram-negative bacteria, developed to combat infections, particularly those resistant to traditional antibiotics. It operates by inhibiting bacterial enzymes DNA gyrase and topoisomerase IV, which are essential for DNA replication and repair, ultimately leading to bacterial cell death. BAY-Y 3118 has shown promise in preclinical studies for treating challenging infections, especially respiratory and urinary tract infections. Its efficacy against drug-resistant pathogens makes it a valuable candidate in the ongoing search for effective antibacterial therapies.
| Catalog Number | I013378 |
| CAS Number | 151213-16-0 |
| Molecular Formula | C₂₀H₂₁ClFN₃O₃ |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid |
| InChI | InChI=1S/C20H21ClFN3O3/c21-16-17-12(19(26)13(20(27)28)8-25(17)11-3-4-11)6-14(22)18(16)24-7-10-2-1-5-23-15(10)9-24/h6,8,10-11,15,23H,1-5,7,9H2,(H,27,28)/t10-,15+/m0/s1 |
| InChIKey | VRXORHRXNRJZCQ-ZUZCIYMTSA-N |
| SMILES | C1CC2CN(CC2NC1)C3=C(C=C4C(=C3Cl)N(C=C(C4=O)C(=O)O)C5CC5)F |
| Reference | [1]. Fass RJ, et al. In vitro activity of Bay y 3118, a new quinolone. Antimicrob Agents Chemother. 1993 Nov;37(11):2348-57.<br>[2]. García I, et al. Intracellular penetration and activity of BAY Y 3118 in human polymorphonuclear leukocytes. Antimicrob Agents Chemother. 1994 Oct;38(10):2426-9.<br>[3]. Nichterlein T, et al. Bay Y 3118, a new quinolone derivative, rapidly eradicates Listeria monocytogenes from infected mice and L929 cells. Antimicrob Agents Chemother. 1994 Jul;38(7):1501-6. |
