Bazedoxifene (WAY-140424) HCl

• CAT Number: A000287
• CAS Number: 198480-56-7
• Molecular Formula: C30H34N2O3.HCl
• Molecular Weight: 507.06
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CC1=C(N(C2=C1C=C(C=C2)O)CC3=CC=C(C=C3)OCCN4CCCCCC4)C5=CC=C(C=C5)O.Cl

Bazedoxifene HCl (WAY-140424, TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively.

Reference

[1] Miller CP, et al. J Med Chem, 2001, 44(11), 1654-1657.
[2] Diane M Biskobing, et al. Clin Interv Aging, 2007, 2(3), 299–303.
[3] Komm BS, et al. Endocrinology, 2005, 146(9), 3999-4008.