For research use only. Not for therapeutic Use.
BBT(CAT: I040845) is a potent enhancer of impaired glucose-stimulated insulin secretion (GSIS), demonstrating promising anti-hyperglycemic activity in type 2 diabetes models. It protects pancreatic β-cells from cytokine- or streptozotocin (STZ)-induced apoptosis, supporting β-cell survival and function under diabetic stress conditions. Mechanistically, BBT exerts its effects through activation of the cAMP/PKA signaling cascade and the L-type voltage-dependent Ca²⁺ channel/CaMK2 pathway, which are critical for insulin secretion and β-cell viability. BBT is a valuable research tool for studying β-cell preservation, insulin signaling, and novel therapeutic approaches in diabetes and metabolic disease research.
| CAS Number | 445000-45-3 |
| Synonyms | N-(2-benzoylphenyl)-5-bromothiophene-2-carboxamide |
| Molecular Formula | C18H12BrNO2S |
| Purity | ≥95% |
| IUPAC Name | N-(2-benzoylphenyl)-5-bromothiophene-2-carboxamide |
| InChI | InChI=1S/C18H12BrNO2S/c19-16-11-10-15(23-16)18(22)20-14-9-5-4-8-13(14)17(21)12-6-2-1-3-7-12/h1-11H,(H,20,22) |
| InChIKey | FCSCANHTNNHZOH-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C(=O)C2=CC=CC=C2NC(=O)C3=CC=C(S3)Br |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
