BBT594

For research use only. Not for therapeutic Use.

  • CAT Number: I005303
  • CAS Number: 882405-89-2
  • Molecular Formula: C28H30F3N7O3
  • Molecular Weight: 569.58
  • Purity: ≥95%
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BBT594(CAT: I005303) is indeed a small molecule inhibitor that has been developed as a potential treatment for cancer. It works by inhibiting the activity of multiple receptor tyrosine kinases (RTKs), including RET and JAK2, which are proteins involved in the signaling pathways that control cell growth and division. By blocking these RTKs, BBT594 can inhibit the growth and survival of cancer cells and prevent the formation of new blood vessels that are necessary for tumor growth and metastasis. BBT594 has shown promising results in preclinical studies and has been evaluated in early-stage clinical trials for the treatment of various types of cancer, including non-small cell lung cancer and glioblastoma.


Catalog Number I005303
CAS Number 882405-89-2
Synonyms

BBT594; BBT-594;BBT 594;

Molecular Formula C28H30F3N7O3
Purity ≥95%
Target RET
Solubility DMSO: ≥ 35 mg/mL
Storage 0 – 4 under dry condition
InChI InChI=1S/C28H30F3N7O3/c1-18(39)34-25-15-26(33-17-32-25)41-22-5-6-24-19(13-22)7-8-38(24)27(40)35-21-4-3-20(23(14-21)28(29,30)31)16-37-11-9-36(2)10-12-37/h3-6,13-15,17H,7-12,16H2,1-2H3,(H,35,40)(H,32,33,34,39)
InChIKey VQLNKQZLPGLOSI-UHFFFAOYSA-N
SMILES O=C(N1CCC2=C1C=CC(OC3=NC=NC(NC(C)=O)=C3)=C2)NC4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4
Reference

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[1]. Morandi A, et al. GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors. Cancer Res. 2013 Jun 15;73(12):3783-95. <br />
[2]. Andreucci E, et al. Targeting the receptor tyrosine kinase RET in combination with aromatase inhibitors in ER positive breast cancer xenografts. Oncotarget. 2016 Sep 2. doi: 10.18632/oncotarget.11826. [Epub ahead of print]
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