For research use only. Not for therapeutic Use.
BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice[1].
BC-1258 是一种 F-box/LRR-重复蛋白 2 (FBXL2) 激活剂，可以稳定和上调 FBXL2 水平。BC-1258 诱导致瘤细胞凋亡，并显着抑制小鼠的肿瘤形成。
BC-1258 (30 μg/mL in the drinking water) significantly reduces tumor size and weight in athymic nude mice[1].
| Catalog Number | I012794 |
| CAS Number | 1507370-40-2 |
| Synonyms | N,N’-bis[[4-(1,3-thiazol-2-yl)phenyl]methyl]ethane-1,2-diamine |
| Molecular Formula | C22H22N4S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H22N4S2/c1-5-19(21-25-11-13-27-21)6-2-17(1)15-23-9-10-24-16-18-3-7-20(8-4-18)22-26-12-14-28-22/h1-8,11-14,23-24H,9-10,15-16H2 |
| InChIKey | FRTSLZJCGAFSET-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1CNCCNCC2=CC=C(C=C2)C3=NC=CS3)C4=NC=CS4 |
| Reference | [1]. Chen BB, et, al. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis. Cell Death Dis. 2013 Aug 8;4(8):e759. |
