For research use only. Not for therapeutic Use.
BC-LI-0186 (Cat.No:I023062) is a potent, selective and cell-permeable inhibitor of GSK-3β with an IC50 value of 10 nM. It shows significant neuroprotective effects in various disease models such as Alzheimer’s and Parkinson’s diseases. It also enhances the differentiation of embryonic stem cells into neurons.
| Catalog Number | I023062 |
| CAS Number | 695207-56-8 |
| Synonyms | BC-LI-0186; BC-LI 0186; BC-LI0186; BCLI-0186; BCLI 0186; BCLI0186; |
| Molecular Formula | C22H27N3O4S |
| Purity | 98% |
| Target | Aminoacyl-tRNA Synthetase |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| IUPAC Name | 4-[2,5-Dihydro-2,3-dimethyl-4-(1-methylethyl)-5-oxo-1H-pyrazol-1-yl]-N-(2-phenoxyethyl)benzenesulfonamide |
| InChI | InChI=1S/C22H27N3O4S/c1-16(2)21-17(3)24(4)25(22(21)26)18-10-12-20(13-11-18)30(27,28)23-14-15-29-19-8-6-5-7-9-19/h5-13,16,23H,14-15H2,1-4H3 |
| InChIKey | SQYWMHPZMHDCHP-UHFFFAOYSA-N |
| SMILES | O=S(C1=CC=C(N2N(C)C(C)=C(C(C)C)C2=O)C=C1)(NCCOC3=CC=CC=C3)=O |
| Reference | 1: Kim JH, Lee C, Lee M, Wang H, Kim K, Park SJ, Yoon I, Jang J, Zhao H, Kim HK, Kwon NH, Jeong SJ, Yoo HC, Kim JH, Yang JS, Lee MY, Lee CW, Yun J, Oh SJ, Kang JS, Martinis SA, Hwang KY, Guo M, Han G, Han JM, Kim S. Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction. Nat Commun. 2017 Sep 29;8(1):732. doi:10.1038/s41467-017-00785-0. PubMed PMID: 28963468; PubMed Central PMCID: PMC5622079. |
