For research use only. Not for therapeutic Use.
BCH001 is a specific PAPD5 inhibitor that restored telomerase activity and telomere length in DC patient induced pluripotent stem cells.
| Catalog Number | I023056 |
| CAS Number | 384859-58-9 |
| Synonyms | BCH001; BCH 001; BCH-001; |
| Molecular Formula | C20H15F3N2O5 |
| Purity | 98% |
| Target | DNA/RNA Synthesis |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-((3-(ethoxycarbonyl)-6-(trifluoromethoxy)quinolin-4-yl)amino)benzoic acid |
| InChI | InChI=1S/C20H15F3N2O5/c1-2-29-19(28)14-10-24-15-8-7-11(30-20(21,22)23)9-13(15)17(14)25-16-6-4-3-5-12(16)18(26)27/h3-10H,2H2,1H3,(H,24,25)(H,26,27) |
| InChIKey | FWJMVZAVAUGMDX-UHFFFAOYSA-N |
| SMILES | FC(F)(F)OC1=CC=C2C(C(NC3=CC=CC=C3C(O)=O)=C(C(OCC)=O)C=N2)=C1 |
| Reference | 1: Nagpal N, Wang J, Zeng J, Lo E, Moon DH, Luk K, Braun RO, Burroughs LM, Keel SB, Reilly C, Lindsley RC, Wolfe SA, Tai AK, Cahan P, Bauer DE, Fong YW, Agarwal S. Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells. Cell Stem Cell. 2020 Jun 4;26(6):896-909.e8. doi: 10.1016/j.stem.2020.03.016. Epub 2020 Apr 21. PMID: 32320679; PMCID: PMC7275922. |
