ABT-199

• CAT Number: I001028
• CAS Number: 1257044-40-8
• Molecular Formula: C₄₅H₅₀ClN₇O₇S
• Molecular Weight: 868.44
• Purity: 98%
• Synonyms: Venetoclax; ABT-199
• Target: BCL2
• Target Protein: P10415
• Solubility: DMSO: ≥ 51 mg/mL
• Appearance: Solid
• Storage: Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
• IC50: Bcl-2:0.01 nM (Ki)
• IUPAC Name: 4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
• InChI: InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54)
• InChIKey: LQBVNQSMGBZMKD-UHFFFAOYSA-N
• SMILES: CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C

ABT-199 (also known as Venetoclax)（Cat No.:I001028）is a highly potent and selective small-molecule inhibitor of the B-cell lymphoma 2 (BCL-2) protein, which plays a key role in regulating apoptosis. By binding to BCL-2, ABT-199 induces programmed cell death in cancer cells, particularly in hematologic malignancies such as chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). Its high specificity and efficacy make it a critical component in targeted cancer therapy. ABT-199 has shown promising results in clinical trials, offering new hope for patients with BCL-2-dependent cancers.