BCN-PEG4-acid

• CAT Number: I016170
• CAS Number: 1881221-47-1
• Molecular Formula: C₂₂H₃₅NO₈
• Molecular Weight: 441.52
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: 3-[2-[2-[2-[2-[[(1R,8S)-9-bicyclo[6.1.0]non-4-ynyl]methoxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C22H35NO8/c24-21(25)7-9-27-11-13-29-15-16-30-14-12-28-10-8-23-22(26)31-17-20-18-5-3-1-2-4-6-19(18)20/h18-20H,3-17H2,(H,23,26)(H,24,25)/t18-,19+,20?
• InChIKey: MOPSTLKSTPBGBX-YOFSQIOKSA-N
• SMILES: C1CC2C(C2COC(=O)NCCOCCOCCOCCOCCC(=O)O)CCC#C1

BCN-PEG4-acid（Cat No.:I016170） is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). It consists of a four-unit polyethylene glycol (PEG) chain with a BCN (trans-cyclooctene) group at one end and an acid moiety at the other end. The BCN group enables conjugation to an antibody or ligand, while the acid moiety allows for release of the drug payload in the target cell’s acidic environment. This linker provides stability during circulation and selective drug release upon internalization, enhancing the therapeutic efficacy of ADCs.

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.