For research use only. Not for therapeutic Use.
BCPA is a Pin1 regulator without cytotoxicity. BCPA attenuates the reduction of Pin1 protein to inhibit receptor activator of RANKL-induced osteoclastogenesis. BCPA regulates osteoclast activation, used to osteoporosis research[1].
| Catalog Number | I040922 |
| CAS Number | 547731-67-9 |
| Synonyms | (E)-3-(2-chlorophenyl)-N-[4-[[(E)-3-(2-chlorophenyl)prop-2-enoyl]amino]butyl]prop-2-enamide |
| Molecular Formula | C22H22Cl2N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H22Cl2N2O2/c23-19-9-3-1-7-17(19)11-13-21(27)25-15-5-6-16-26-22(28)14-12-18-8-2-4-10-20(18)24/h1-4,7-14H,5-6,15-16H2,(H,25,27)(H,26,28)/b13-11+,14-12+ |
| InChIKey | KHDKYKZKDQMAKP-PHEQNACWSA-N |
| SMILES | C1=CC=C(C(=C1)C=CC(=O)NCCCCNC(=O)C=CC2=CC=CC=C2Cl)Cl |
| Reference | [1]. Cho E, et al. BCPA {N, N′-1, 4-Butanediylbis [3-(2-chlorophenyl) acrylamide]} Inhibits osteoclast differentiation through increased retention of peptidyl-prolyl cis-trans isomerase never in mitosis A-interacting 1[J]. International Journal of Molecular Sciences, 2018, 19(11): 3436. |
