For research use only. Not for therapeutic Use.
BCTC (Cat No.: I003440) is a potent and selective antagonist of the TRPV1 (transient receptor potential vanilloid 1) channel, a receptor involved in pain perception, inflammation, and thermoregulation. By blocking TRPV1, which is activated by heat, protons, and capsaicin, BCTC reduces pain signaling in sensory neurons. It is widely used in preclinical research to study the role of TRPV1 in chronic pain, neuropathy, and inflammatory conditions. BCTC has contributed to the development of novel analgesics targeting TRP channels as non-opioid pain relief alternatives.
| CAS Number | 393514-24-4 |
| Synonyms | N-(4-(tert-butyl)phenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide |
| Molecular Formula | C20H25ClN4O |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | 10 mM in DMSO |
| Storage | Store at RT |
| IUPAC Name | N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide |
| InChI | 1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26) |
| InChIKey | ROGUAPYLUCHQGK-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl |
| Reference | </br>1:Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Liu T, Fang Z, Wang G, Shi M, Wang X, Jiang K, Yang Z, Cao R, Tao H, Wang X, Zhou J.Oncol Lett. 2016 Jan;11(1):182-188. Epub 2015 Nov 2. PMID: 26870186 Free PMC Article</br>2:Synthesis of Analogues of BCTC Incorporating a Pyrrolidinyl Linker and Biological Evaluation as Transient Receptor Potential Vanilloid 1 Antagonists. Yan L, Wang J, Pan M, Qiu Q, Huang W, Qian H.Chem Biol Drug Des. 2016 Feb;87(2):306-11. doi: 10.1111/cbdd.12661. Epub 2015 Oct 5. PMID: 26360809 </br>3:Use and limitations of three TRPV-1 receptor antagonists on smooth muscles of animals and man: a vote for BCTC. Benko R, Illényi L, Kelemen D, Papp R, Papp A, Bartho L.Eur J Pharmacol. 2012 Jan 5;674(1):44-50. doi: 10.1016/j.ejphar.2011.10.021. Epub 2011 Oct 25. PMID: 22056835 </br>4:Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath. Tékus V, Bölcskei K, Kis-Varga A, Dézsi L, Szentirmay E, Visegrády A, Horváth C, Szolcsányi J, Petho G.Eur J Pharmacol. 2010 Sep 1;641(2-3):135-41. doi: 10.1016/j.ejphar.2010.05.052. Epub 2010 Jun 8. PMID: 20534382 </br>5:N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties. Valenzano KJ, Grant ER, Wu G, Hachicha M, Schmid L, Tafesse L, Sun Q, Rotshteyn Y, Francis J, Limberis J, Malik S, Whittemore ER, Hodges D.J Pharmacol Exp Ther. 2003 Jul;306(1):377-86. Epub 2003 Apr 29. PMID: 12721338 Free Article</br>6:N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain. Pomonis JD, Harrison JE, Mark L, Bristol DR, Valenzano KJ, Walker K.J Pharmacol Exp Ther. 2003 Jul;306(1):387-93. Epub 2003 Apr 29. PMID: 12721336 Free Article |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
