BCX 1470 methanesulfonate

• CAT Number: I002660
• CAS Number: 217099-44-0
• Molecular Formula: C15H14N2O5S3
• Molecular Weight: 398.48
• Purity: ≥95%
• Synonyms: (2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate;methanesulfonic acid
• Target: Complement System
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) [1]
• InChI: InChI=1S/C14H10N2O2S2.CH4O3S/c15-13(16)12-6-8-3-4-9(7-11(8)20-12)18-14(17)10-2-1-5-19-10;1-5(2,3)4/h1-7H,(H3,15,16);1H3,(H,2,3,4)
• InChIKey: MCPAUXMAIOICMC-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)O.C1=CSC(=C1)C(=O)OC2=CC3=C(C=C2)C=C(S3)C(=N)N

BCX 1470 methanesulfonate (Cat.No:I002660) is a potent and selective inhibitor of dipeptidyl peptidase II (DPP II), an enzyme involved in the regulation of immune response and inflammation. This compound has been studied for its potential therapeutic applications in autoimmune diseases, cancer, and viral infections.

Reference

[1]. Szalai, Alexander J.; Digerness, Stanley B.; et al.; The Arthus Reaction in Rodents: Species-Specific Requirement of ComplementJournal of Immunology, 2000, 164, 463-468
[2]. Szalai AJ, Digerness SB, Agrawal A, Kearney JF, Bucy RP, Niwas S, Kilpatrick JM, Babu YS, Volanakis JE.The Arthus reaction in rodents: species-specific requirement of complement.J Immunol. 2000 Jan 1;164(1):463-8.