BCX4430 freebase

• CAT Number: I002846
• CAS Number: 249503-25-1
• Molecular Formula: C11H15N5O3
• Molecular Weight: 265.30
• Purity: ≥95%
• Synonyms: Immucillin A
• Target: Anti-infection
• Solubility: 10 mM in H2O
• Storage: -20°C
• IUPAC Name: (2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol
• InChI: InChI=1S/C11H15N5O3/c12-11-8-6(14-3-15-11)4(1-13-8)7-10(19)9(18)5(2-17)16-7/h1,3,5,7,9-10,13,16-19H,2H2,(H2,12,14,15)/t5-,7+,9-,10+/m1/s1
• InChIKey: AMFDITJFBUXZQN-KUBHLMPHSA-N
• SMILES: C1=C(C2=C(N1)C(=NC=N2)N)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O

BCX4430 freebase（Cat No.:I002846）is a nucleoside analog developed by BioCryst Pharmaceuticals, primarily investigated for its antiviral properties. It is the freebase form of BCX4430, which is converted into an active form within the body. The compound inhibits RNA-dependent RNA polymerase, preventing viral replication. BCX4430 has shown activity against a range of RNA viruses, including filoviruses like Ebola and arenaviruses. It has demonstrated efficacy in preclinical studies and early-phase clinical trials. BCX4430 freebase holds promise as a treatment for viral hemorrhagic fevers and other severe viral infections, although further clinical development is ongoing.