BD750

For research use only. Not for therapeutic Use.

  • CAT Number: I045830
  • CAS Number: 892686-59-8
  • Molecular Formula: C14H13N3OS
  • Molecular Weight: 271.34
  • Purity: ≥95%
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BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively[1][2].
BD750 inhibits human T cell proliferation stimulated either by anti-CD3/anti-CD28 mAbs or by alloantigen in a dose-dependent manner with IC50 values of 1.1 ± 0.2 μM and 1.3 ± 0.2 μM respectively[1].
BD750 also inhibits ConA, PMA/ionomycine or alloantigen-induced mouse T cell proliferation and PHA or PMA/ionomycine-induced human T cell proliferation[1].
BD750 (5 or 20 μM) inhibits the LPS-induced JAK-STAT5 signaling in DC[2].
BD750 can induce tolerogenic dendritic cells (tolDC) and their function in experimental autoimmune encephalitis (EAE) in mice[2].


Catalog Number I045830
CAS Number 892686-59-8
Synonyms

2-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydro-1H-indazol-3-one

Molecular Formula C14H13N3OS
Purity ≥95%
InChI InChI=1S/C14H13N3OS/c18-13-9-5-1-2-6-10(9)16-17(13)14-15-11-7-3-4-8-12(11)19-14/h3-4,7-8,16H,1-2,5-6H2
InChIKey QWUHPPCZZXKXOQ-UHFFFAOYSA-N
SMILES C1CCC2=C(C1)C(=O)N(N2)C3=NC4=CC=CC=C4S3
Reference

[1]. Y Liu, et al. BD750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK3/STAT5 signalling pathway. Br J Pharmacol. 2013 Feb;168(3):632-43.
 [Content Brief]

[2]. Yan Zhou, et al. Tolerogenic dendritic cells induced by BD750 ameliorate proinflammatory T cell responses and experimental autoimmune encephalitis in mice. Mol Med. 2017 Oct;23:204-214.
 [Content Brief]

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