For research use only. Not for therapeutic Use.
BDM41906(CAT: I023074) is a specific and potent inhibitor of EthR, a transcriptional repressor involved in the resistance mechanism against ethionamide (ETH) in Mycobacterium tuberculosis. By inhibiting EthR, BDM41906 enhances the activation of ethionamide, significantly boosting its antibacterial efficacy—up to fourfold in intravenously infected tuberculosis (TB) mouse models. This compound is a valuable tool in TB research, particularly for exploring combination therapies aimed at overcoming drug resistance and improving treatment outcomes. Its targeted mechanism underscores its potential in advancing therapeutic strategies for multidrug-resistant TB.
| Catalog Number | I023074 |
| Synonyms | BDM-41906; BDM 41906; BDM41906 |
| Molecular Formula | C15H17F3N4O2S |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 5,5,5-Trifluoro-1-[4-(3-thiazol-2-yl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-pentan-1-one |
| InChI | InChI=1S/C15H17F3N4O2S/c16-15(17,18)5-1-2-11(23)22-7-3-10(4-8-22)13-20-12(21-24-13)14-19-6-9-25-14/h6,9-10H,1-5,7-8H2 |
| InChIKey | WIFDOUQOJULUSV-UHFFFAOYSA-N |
| SMILES | O=C(N1CCC(C2=NC(C3=NC=CS3)=NO2)CC1)CCCC(F)(F)F |
