For research use only. Not for therapeutic Use.
Beauvericin(cas 26048-05-5) is a cyclic depsipeptide isolated from several fungal genera, notably Beauveria and Fusarium, first reported in
1969. Beauvericin exhibits broad antifungal, antibacterial, antiprotozoan and insecticidal activities. At the molecular level,
beauvericin exhibits ionophore properties, and inhibits acyl-CoA:cholesterol acyltransferase activity. Beauvericin induces
apoptosis by elevating intracellular calcium levels.
| Catalog Number | R013931 |
| CAS Number | 26048-05-5 |
| Synonyms | Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl]; |
| Molecular Formula | C45H57N3O9 |
| Purity | 97% |
| Appearance | White Powder |
| Storage | -20°C |
| Analysis method | HPLC |
| IUPAC Name | (3S,6R,9S,12R,15S,18R)-3,9,15-tribenzyl-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone |
| InChI | InChI=1S/C45H57N3O9/c1-28(2)37-40(49)46(7)35(26-32-21-15-11-16-22-32)44(53)56-39(30(5)6)42(51)48(9)36(27-33-23-17-12-18-24-33)45(54)57-38(29(3)4)41(50)47(8)34(43(52)55-37)25-31-19-13-10-14-20-31/h10-24,28-30,34-39H,25-27H2,1-9H3/t34-,35-,36-,37+,38+,39+/m0/s1 |
| InChIKey | GYSCAQFHASJXRS-FFCOJMSVSA-N |
| SMILES | CC(C)C1C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)O1)CC2=CC=CC=C2)C)C(C)C)CC3=CC=CC=C3)C)C(C)C)CC4=CC=CC=C4)C |
| Reference | The structure of beauvericin, a new depsipeptide antibiotic toxic to Artemia salina. Hamill Z. R. L. et al. Tet. Letters 1969, 4255. <br /> |
