For research use only. Not for therapeutic Use.
BEC HCl is a slow-binding, competitive arginase inhibitor with Ki values of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively. BEC resulted in a significant enhancement of NO-dependent smooth muscle contraction. In cardiomyocytes, BECs enhanced Ca(2+)-dependent NOS activity and NO production while increasing their basal contractility.
| Catalog Number | I002706 |
| CAS Number | 222638-67-7 |
| Synonyms | S-(2-boronoethyl)-L-cysteine, monohydrochloride |
| Molecular Formula | C5H12BNO4S • HCl |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Solubility | 45 mg/mL in H2O; 45 mg/mL in DMSO. |
| Storage | -20°C |
| IUPAC Name | (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid;hydrochloride |
| InChI | InChI=1S/C5H12BNO4S.ClH/c7-4(5(8)9)3-12-2-1-6(10)11;/h4,10-11H,1-3,7H2,(H,8,9);1H/t4-;/m0./s1 |
| InChIKey | GHPYJLCQYMAXGG-WCCKRBBISA-N |
| SMILES | B(CCSCC(C(=O)O)N)(O)O.Cl |
| Reference | <p style=/line-height:25px/> <br>[2]. Kim NN et al. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001 Mar 6;40(9):2678-88. <br>[3]. Karina Ckless et al. Inhibition of Arginase Activity Enhances Inflammation in Mice with Allergic Airway Disease, in Association with Increases in Protein S-Nitrosylation and Tyrosine Nitration. J Immunol. Author manuscript; available in PMC 2010 Jun 28. <br>[4]. Steppan J et al. Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4759-64. </p> |
