Beclomethasone 21-Propionate-d5

• CAT Number: R046494
• CAS Number: NA
• Molecular Formula: C₂₅H₂₈D₅ClO₆
• Molecular Weight: 470.01
• Purity: ≥95%
• Synonyms: (11β,16β)-9-Chloro-11,17-dihydroxy-16-methyl-21-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione-d5; Beclomethasone 21-Monopropionate-d5
• Storage: -20°C
• IUPAC Name: [2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2,3,3,3-pentadeuteriopropanoate
• InChI: InChI=1S/C25H33ClO6/c1-5-21(30)32-13-20(29)25(31)14(2)10-18-17-7-6-15-11-16(27)8-9-22(15,3)24(17,26)19(28)12-23(18,25)4/h8-9,11,14,17-19,28,31H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1/i1D3,5D2
• InChIKey: OPNPEZLXXKGRTA-BFHSNLKKSA-N
• SMILES: [2H]C([2H])([2H])C([2H])([2H])C(=O)OCC(=O)[C@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)Cl)O)C)C)O

Beclomethasone 21-Propionate-d5 is a deuterated form of beclomethasone 21-propionate, a potent corticosteroid used primarily in the treatment of inflammatory conditions such as asthma and allergic rhinitis. This compound features five deuterium atoms, which enhance its stability and allow for precise tracking in pharmacokinetic studies, drug metabolism research, and isotope-dilution mass spectrometry. Beclomethasone 21-Propionate-d5 is particularly valuable in investigating the absorption, distribution, metabolism, and excretion (ADME) of beclomethasone in biological systems. It serves as a reliable internal standard in analytical chemistry, ensuring accurate and reproducible results in the development and optimization of corticosteroid therapies, especially in studying the pharmacokinetics and bioavailability of beclomethasone-related compounds.