For research use only. Not for therapeutic Use.
Belotecan-d7 Hydrochloride (CAS: 1346598-22-8), a premium pharmaceutical research compound designed for advanced oncology and chemotherapy studies. As a deuterated analog of Belotecan hydrochloride, it offers enhanced stability and improved pharmacokinetic properties. Belotecan-d7 Hydrochloride is ideal for use in pharmacological and biochemical research, providing precise and reliable data for your studies. This high-purity compound ensures consistent results, aiding in the development of novel cancer therapies. Trusted by leading laboratories, Belotecan-d7 Hydrochloride is your go-to solution for cutting-edge cancer research. Unlock new possibilities in oncology treatment with Belotecan-d7 Hydrochloride, where innovation meets reliability.
| Catalog Number | S000130 |
| CAS Number | 1346598-22-8 |
| Molecular Formula | C25H21D7ClN3O4 |
| Purity | ≥95% |
| Target | Topoisomerase |
| IUPAC Name | (19S)-19-ethyl-10-[2-(1,1,1,2,3,3,3-heptadeuteriopropan-2-ylamino)ethyl]-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione;hydrochloride |
| InChI | InChI=1S/C25H27N3O4.ClH/c1-4-25(31)19-11-21-22-17(12-28(21)23(29)18(19)13-32-24(25)30)15(9-10-26-14(2)3)16-7-5-6-8-20(16)27-22;/h5-8,11,14,26,31H,4,9-10,12-13H2,1-3H3;1H/t25-;/m0./s1/i2D3,3D3,14D; |
| InChIKey | SJKBXKKZBKCHET-RJGVUDMNSA-N |
| SMILES | [2H]C([2H])([2H])C([2H])(C([2H])([2H])[2H])NCCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=CC=CC=C51.Cl |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Kim YK, et al. Anticancer effects of CKD-602 (Camtobell?) via G2/M phase arrest in oral squamous cell carcinoma cell lines. Oncol Lett. 2015 Jan;9(1):136-142. [3]. Kim YY, et al. CKD-602, a camptothecin derivative, inhibits proliferation and induces apoptosis in glioma cell lines. Oncol Rep. 2009 Jun;21(6):1413-9. [4]. Kim CY, et al. Antitumor activity of CKD-602, a camptothecin derivative, in a mouse glioma model. J Clin Neurosci. 2012 Feb;19(2):301-5. |
