Benazepril-d5

• CAT Number: R005046
• CAS Number: 1279200-03-1
• Molecular Formula: C24H28N2O5
• Molecular Weight: 429.528
• Purity: ≥95%
• Synonyms: (3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic Acid; Lotensin
• Storage: 4°C
• IUPAC Name: 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-(2,3,4,5,6-pentadeuteriophenyl)butan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
• InChI: InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1/i3D,4D,5D,8D,9D
• InChIKey: XPCFTKFZXHTYIP-DPINEGQSSA-N
• SMILES: [2H]C1=C(C(=C(C(=C1[2H])[2H])CC[C@@H](C(=O)OCC)N[C@H]2CCC3=CC=CC=C3N(C2=O)CC(=O)O)[2H])[2H]

Benazepril-d5 is a deuterated form of benazepril, with five deuterium atoms incorporated into its molecular structure. This high-purity isotopically labeled compound is essential for research in cardiovascular pharmacology, drug metabolism, and pharmacokinetics. Benazepril-d5 is particularly valuable for studying the metabolic pathways, pharmacokinetics, and therapeutic efficacy of benazepril, an angiotensin-converting enzyme (ACE) inhibitor used to treat hypertension and heart failure. The deuterium labeling allows for precise tracking and quantification in biological systems using mass spectrometry, enhancing the accuracy of studies on drug absorption, distribution, metabolism, and excretion. This compound is a critical tool for researchers focused on optimizing ACE inhibitor therapies, understanding drug interactions, and investigating the pharmacodynamics of benazepril in cardiovascular conditions, providing consistent and reliable results in various experimental applications.