For research use only. Not for therapeutic Use.
Benazepril Hydrochloride is the hydrochloride salt of benazepril, a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. Benazepril hydrochloride reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.
| Catalog Number | A000228 |
| CAS Number | 86541-74-4 |
| Synonyms | Benazepril HCl; 86541-74-4; Lotensin; Cibacene; Briem |
| Molecular Formula | C24H29ClN2O5 |
| Purity | ≥95% |
| Target | Angiotensin-converting Enzyme (ACE) |
| Storage | -20°C |
| InChI | 1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1 |
| InChIKey | VPSRQEHTHIMDQM-FKLPMGAJSA-N |
| SMILES | CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O.Cl |
| Reference | 1: Xue L, Feng X, Wang C, Zhang X, Sun W, Yu K. Benazepril hydrochloride improves 2: Vollmar AC, Fox PR. Long-term Outcome of Irish Wolfhound Dogs with Preclinical <br> <br> 5: Qian M, Chen T, Zhou D, Zhang Z, Zhang Q, Tang S, Xiao X. Development of a new 6: Naguib IA, Abdelaleem EA, Draz ME, Zaazaa HE. Linear support vector regression <br> <br> <br> <br> |
