Benfotiamine

• CAT Number: I002728
• CAS Number: 22457-89-2
• Molecular Formula: C19H23N4O6PS
• Molecular Weight: 466.45
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: -20°C

Benfotiamine is a synthetic S-acyl derivative of thiamine (vitamin B1); an antioxidant dietary supplement.IC50 value:Target:Benfotiamine, the lipid-soluble thiamine derivative used as a treatment for diabetic neuropathy, can inhibit three major pathways(the hexosamine pathway, the advanced glycation end product (AGE) formation pathway and the diacylglycerol (DAG)protein kinase C (PKC) pathway）of hyperglycemic damage and prevent experimental diabetic retinopathy. Benfotiamine is a synthetic S-acyl derivative of thiamine (vitamin B1) for treating sciatica and other painful nerve conditions. More effective at increasing thiamin levels in blood and tissues than water-soluble salts like the previous vitamin B1.

Reference

1:Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels. Vignisse J, Sambon M, Gorlova A, Pavlov D, Caron N, Malgrange B, Shevtsova E, Svistunov A, Anthony DC, Markova N, Bazhenova N, Coumans B, Lakaye B, Wins P, Strekalova T, Bettendorff L.Mol Cell Neurosci. 2017 May 12. pii: S1044-7431(16)30270-6. doi: 10.1016/j.mcn.2017.05.005. [Epub ahead of print] PMID: 28506637 2:Thiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stress-induced behaviours in mice. Markova N, Bazhenova N, Anthony DC, Vignisse J, Svistunov A, Lesch KP, Bettendorff L, Strekalova T.Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75:148-156. doi: 10.1016/j.pnpbp.2016.11.001. Epub 2016 Nov 5. PMID: 27825907 3:Chromatographic Analysis of a Multicomponent Mixture of B1, B6, B12, Benfotiamine, and Diclofenac; Part I: HPLC and UPLC Methods for the Simultaneous Quantification of These Five Components in Tablets and Capsules. Fayed AS, Hegazy MA, Wahab NS.J AOAC Int. 2016 Nov 1;99(6):1513-1521. doi: 10.5740/jaoacint.16-0023. Epub 2016 Oct 1. PMID: 27697097 4:Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer/’s Disease. Pan X, Chen Z, Fei G, Pan S, Bao W, Ren S, Guan Y, Zhong C.Neurosci Bull. 2016 Dec;32(6):591-596. Epub 2016 Oct 1. PMID: 27696179 5:Protective effect of treatment with thiamine or benfotiamine on liver oxidative damage in rat model of acute ethanol intoxication. Portari GV, Ovidio PP, Deminice R, Jordão AA Jr.Life Sci. 2016 Oct 1;162:21-4. doi: 10.1016/j.lfs.2016.08.017. Epub 2016 Aug 18. PMID: 27545821 6:Benfotiamine upregulates antioxidative system in activated BV-2 microglia cells. Bozic I, Savic D, Stevanovic I, Pekovic S, Nedeljkovic N, Lavrnja I.Front Cell Neurosci. 2015 Sep 4;9:351. doi: 10.3389/fncel.2015.00351. eCollection 2015. PMID: 26388737 Free PMC Article7:Pharmacokinetics of the transdermal delivery of benfotiamine. Zhu Z, Varadi G, Carter SG.Acta Diabetol. 2016 Apr;53(2):317-22. doi: 10.1007/s00592-015-0776-2. Epub 2015 Jul 4. PMID: 26141141 8:Change in psychiatric symptomatology after benfotiamine treatment in males is related to lifetime alcoholism severity. Manzardo AM, Pendleton T, Poje A, Penick EC, Butler MG.Drug Alcohol Depend. 2015 Jul 1;152:257-63. doi: 10.1016/j.drugalcdep.2015.03.032. Epub 2015 Apr 8. PMID: 25908323 Free PMC Article9:Paraptosis cell death induction by the thiamine analog benfotiamine in leukemia cells. Sugimori N, Espinoza JL, Trung LQ, Takami A, Kondo Y, An DT, Sasaki M, Wakayama T, Nakao S.PLoS One. 2015 Apr 7;10(4):e0120709. doi: 10.1371/journal.pone.0120709. eCollection 2015. PMID: 25849583 Free PMC Article10:Effect of benfotiamine in podocyte damage induced by peritoneal dialysis fluid. Müller-Krebs S, Nissle K, Tsobaneli J, Zeier M, Kihm LP, Kender Z, Fleming T, Nawroth PP, Reiser J, Schwenger V.Front Med (Lausanne). 2015 Mar 10;2:10. doi: 10.3389/fmed.2015.00010. eCollection 2015. PMID: 25806370 Free PMC Article