For research use only. Not for therapeutic Use.
Benoxathian hydrochloride is a potent α1 adrenoceptor antagonist, can be used for researching anorexia[1].
Benoxathian hydrochloride (10 nM; paraventricular nucleus injection) completely reverses the anorexia induced by 2.5, 5.0 or 10.0 mg/kg Phenylpropanolamine (IP) in rats[1].
| Catalog Number | I043466 |
| CAS Number | 92642-97-2 |
| Synonyms | N-(2,3-dihydro-1,4-benzoxathiin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine;hydrochloride |
| Molecular Formula | C19H24ClNO4S |
| Purity | ≥95% |
| InChI | InChI=1S/C19H23NO4S.ClH/c1-21-16-7-5-8-17(22-2)19(16)23-11-10-20-12-14-13-25-18-9-4-3-6-15(18)24-14;/h3-9,14,20H,10-13H2,1-2H3;1H |
| InChIKey | OWRADFDDJVNMGL-UHFFFAOYSA-N |
| SMILES | COC1=C(C(=CC=C1)OC)OCCNCC2CSC3=CC=CC=C3O2.Cl |
| Reference | [1]. Wellman PJ, et al. Reversal of phenylpropanolamine anorexia in rats by the alpha-1 receptor antagonist benoxathian. Pharmacol Biochem Behav. 1991 Apr;38(4):905-8. |
