Benperidol

For research use only. Not for therapeutic Use.

  • CAT Number: I004156
  • CAS Number: 2062-84-2
  • Molecular Formula: C22H24FN3O2
  • Molecular Weight: 381.45
  • Purity: ≥95%
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Benperidol (Cat.No:I004156), also known as Anquil and R-4584, is a butyrophenone antipsychotic, with the highest neuroleptic potency in terms of D2 receptor blockade. Benperidol can be used for positron emission tomography (PET) measurements of D(2)-like dopamine receptor binding in vivo.


Catalog Number I004156
CAS Number 2062-84-2
Synonyms

Benperidol; R-4584; R 4584; R4584; Anquil; McN-JR-4584; McN JR 4584; McNJR4584;1-(1-(4-(4-fluorophenyl)-4-oxobutyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Molecular Formula C22H24FN3O2
Purity ≥95%
Solubility Soluble in DMSO
Storage 0 - 4 °C for short term or -20 °C for long term
IUPAC Name 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl]-1H-benzimidazol-2-one
InChI InChI=1S/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28)
InChIKey FEBOTPHFXYHVPL-UHFFFAOYSA-N
SMILES C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
Reference

</br>1:A comparison of D2 receptor specific binding in obese and normal-weight individuals using PET with (N-[(11)C]methyl)benperidol. Eisenstein SA, Antenor-Dorsey JA, Gredysa DM, Koller JM, Bihun EC, Ranck SA, Arbeláez AM, Klein S, Perlmutter JS, Moerlein SM, Black KJ, Hershey T.Synapse. 2013 Nov;67(11):748-56. doi: 10.1002/syn.21680. Epub 2013 May 30. PMID: 23650017 Free PMC Article</br>2:Characterization of extrastriatal D2 in vivo specific binding of [¹⁸F](N-methyl)benperidol using PET. Eisenstein SA, Koller JM, Piccirillo M, Kim A, Antenor-Dorsey JA, Videen TO, Snyder AZ, Karimi M, Moerlein SM, Black KJ, Perlmutter JS, Hershey T.Synapse. 2012 Sep;66(9):770-80. doi: 10.1002/syn.21566. Epub 2012 May 15. PMID: 22535514 Free PMC Article</br>3:Validation of the reference tissue model for estimation of dopaminergic D2-like receptor binding with [18F](N-methyl)benperidol in humans. Antenor-Dorsey JA, Markham J, Moerlein SM, Videen TO, Perlmutter JS.Nucl Med Biol. 2008 Apr;35(3):335-41. doi: 10.1016/j.nucmedbio.2007.12.004. PMID: 18355689 Free PMC Article</br>4:Radiation dosimetry of N-([11C]methyl)benperidol as determined by whole-body PET imaging of primates. Antenor-Dorsey JA, Laforest R, Moerlein SM, Videen TO, Perlmutter JS.Eur J Nucl Med Mol Imaging. 2008 Apr;35(4):771-8. Epub 2007 Dec 11. Erratum in: Eur J Nucl Med Mol Imaging. 2013 May;40(5):795-6. Dosage error in published abstract; MEDLINE/PubMed abstract corrected. PMID: 18071701 Free PMC Article</br>5:Benperidol for schizophrenia. Leucht S, Hartung B.Cochrane Database Syst Rev. 2005 Apr 18;(2):CD003083. Review. PMID: 15846648 </br>6:Complete dopamine D2 receptor occupancy without extrapyramidal side effects under benperidol. Schönfeldt-Lecuona C, Juengling FD, Connemann BJ, Reske SN, Spitzer M, Kassubek J.J Clin Psychopharmacol. 2004 Feb;24(1):97-8. No abstract available. PMID: 14709957 </br>7:In vivo measurement of D2 receptor density and affinity for 18F-(3-N-methyl)benperidol in the rat striatum with a PET system for small laboratory animals. Nikolaus S, Larisch R, Beu M, Hamacher K, Forutan F, Vosberg H, Müller HW.J Nucl Med. 2003 Apr;44(4):618-24. PMID: 12679408 Free Article</br>8:Benperidol for schizophrenia. Leucht S, Hartung B.Cochrane Database Syst Rev. 2002;(1):CD003083. Review. Update in: Cochrane Database Syst Rev. 2005;(2):CD003083. PMID: 11869652 </br>9:Imaging of striatal dopamine D(2) receptors with a PET system for small laboratory animals in comparison with storage phosphor autoradiography: a validation study with (18)F-(N-methyl)benperidol. Nikolaus S, Larisch R, Beu M, Vosberg H, Müller-Gärtner HW.J Nucl Med. 2001 Nov;42(11):1691-6. PMID: 11696641 Free Article</br>10:In vivo kinetics of [18F](N-methyl)benperidol: a novel PET tracer for assessment of dopaminergic D2-like receptor binding. Moerlein SM, Perlmutter JS, Markham J, Welch MJ.J Cereb Blood Flow Metab. 1997 Aug;17(8):833-45. PMID: 9290581

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