For research use only. Not for therapeutic Use.
Bentazepam is a thienodiazepine which is a benzodiazepine analog. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Peak plasma rates are achieved in around 2,5 hours after oral administration.
| Catalog Number | R032444 |
| CAS Number | 29462-18-8 |
| Synonyms | CI 718; QM 6008; Thiadipone; Tiadipone |
| Molecular Formula | C17H16N2OS |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | 5-phenyl-3,4,6,7,8,9-hexahydro-[1]benzothiolo[2,3-e][1,4]diazepin-2-one |
| InChI | InChI=1S/C17H16N2OS/c20-14-10-18-16(11-6-2-1-3-7-11)15-12-8-4-5-9-13(12)21-17(15)19-14/h1-3,6-7,18H,4-5,8-10H2 |
| InChIKey | CXEGHCTZKNQDGO-UHFFFAOYSA-N |
| SMILES | C1CCC2=C(C1)C3=C(NCC(=O)N=C3S2)C4=CC=CC=C4 |
| Reference | </br>1:[Acute hepatitis due to bentazepam]. Andrade RJ, López-Torres E, Lucena MI, Fernández Mdel C.Med Clin (Barc). 2003 May 10;120(17):678-9. Spanish. No abstract available. PMID: 12747823 </br>2:Chronic liver injury related to use of bentazepam: an unusual instance of benzodiazepine hepatotoxicity. Andrade RJ, Lucena MI, Aguilar J, Lazo MD, Camargo R, Moreno P, García-Escaño MD, Marquez A, Alcántara R, Alcáin G.Dig Dis Sci. 2000 Jul;45(7):1400-4. PMID: 10961721 </br>3:Bentazepam-induced hepatic bridging necrosis. de-la-Serna C, Gil-Grande LA, Sanromán AL, Gonzalez M, Ruiz-del-Arbol L, Garcia Plaza A.J Clin Gastroenterol. 1997 Dec;25(4):710-1. No abstract available. PMID: 9451703 </br>4:Bentazepam-associated chronic liver disease. Andrade RJ, Lucena MI, Alcantara R, Fraile JM.Lancet. 1994 Apr 2;343(8901):860. No abstract available. PMID: 7908109 </br>5:Open-loop feedback control of serum bentazepam concentrations and Bayesian estimation in multiple dosage regimens in patients. Colino CI, Lastra CF, López FG, Ledesma A, Mariño EL.Int J Clin Pharmacol Ther Toxicol. 1991 Nov;29(11):457-62. PMID: 1800395 </br>6:[A pharmacovigilance study with bentazepam in a sample of 1046 psychiatric outpatients]. Honorato J, Rubio A, Tristán C, Otero FJ, Garrido J.Rev Med Univ Navarra. 1990 Apr-Jun;34(2):80-8. Spanish. PMID: 1983365 </br>7:Discrimination of kinetic models in heteroscedastic parametric estimation of bentazepam following multiple dosing. Fernandez Lastra C, Gonzalez Lopez F, Dominguez-Gil A, Mariño EL.Int J Clin Pharmacol Ther Toxicol. 1988 Jul;26(7):335-8. PMID: 3209281 </br>8:Simulation of plasma bentazepam levels in multiple dosage regimens from parameters established by non-linear regression and bayesian estimation. Mariño EL, Fernandez Lastra C, Gonzalez Lopez F, Martin Rey A, Dominguez-Gil A, Garcia-Santalla JL, Llorca G, Izquiexdo JA, Ledesma-Jimeno A.Int J Clin Pharmacol Ther Toxicol. 1987 Dec;25(12):664-9. PMID: 2893777 </br>9:Parametrization by non-linear regression and bayesian estimation of bentazepam in a multiple dosage regimen in humans. Mariño EL, Fernandez Lastra C, Gonzalez Lopez F, Dominguez-Gil A, Garcia Santalla JL, Vorca G, Izquierdo JA, Ledesma-Jimeno A.Int J Clin Pharmacol Ther Toxicol. 1987 Nov;25(11):627-32. PMID: 3429066 </br>10:Determination of bentazepam in plasma by high-performance liquid chromatography. Lopez FG, Mariño EL, Dominguez-Gil A.J Pharm Biomed Anal. 1987;5(6):553-8. No abstract available. PMID: 16867478 |
