For research use only. Not for therapeutic Use.
Benvitimod（Cat No.:I002817）is a novel small-molecule anti-inflammatory agent developed for the treatment of psoriasis and other inflammatory skin disorders. It acts by modulating the activity of aryl hydrocarbon receptors (AHRs), which play a crucial role in regulating immune responses and skin homeostasis. By targeting these receptors, benvitimod reduces the production of pro-inflammatory cytokines, alleviating symptoms such as redness, scaling, and itching in psoriatic lesions. Its unique mechanism offers a steroid-free alternative for patients, making benvitimod a promising therapy for long-term management of chronic inflammatory skin conditions.
| Catalog Number | I002817 |
| CAS Number | 79338-84-4 |
| Synonyms | Benvitimod; WB-1001; WBI-1001; WB1001; WBI 1001. GSK-2894512; GSK 2894512; GSK2894512; 3,5-DH4IS; tapinarof;3,5-Dihydroxy-4-isopropylstilbene |
| Molecular Formula | C17H18O2 |
| Purity | 98% |
| Target | Aryl Hydrocarbon Receptor |
| Target Protein | |
| Solubility | Soluble in DMSO |
| Appearance | Solid |
| Storage | Dry, dark and at 2 - 8 °C for six months or -20°C for two years. |
| IC50 | EC50: 13 nM (AhR) |
| IUPAC Name | 5-[(E)-2-phenylethenyl]-2-propan-2-ylbenzene-1,3-diol |
| InChI | InChI=1S/C17H18O2/c1-12(2)17-15(18)10-14(11-16(17)19)9-8-13-6-4-3-5-7-13/h3-12,18-19H,1-2H3/b9-8+ |
| InChIKey | ZISJNXNHJRQYJO-CMDGGOBGSA-N |
| SMILES | CC(C)C1=C(C=C(C=C1O)/C=C/C2=CC=CC=C2)O |
| Reference | </br>1:Use of a dose-response model to guide future clinical trial of benvitimod cream to treat mild and moderate psoriasis. Zang YN, Jiang DL, Cai L, Chen X, Wang Q, Xie ZW, Liu Y, Zhang CY, Jing S, Chen GH, Zhang JZ, Xu L, Feng WY, Zhao LB, Fang Y.Int J Clin Pharmacol Ther. 2016 Feb;54(2):87-95. doi: 10.5414/CP202486. PMID: 26709597 </br>2:Randomized, double-blind, placebo-controlled, multiple-dose study of the safety, tolerability and pharmacokinetics of benvitimod, a candidate drug for the treatment of psoriasis. Zhao L, Chen X, Cai L, Zhang C, Wang Q, Jing S, Chen G, Li J, Zhang J, Fang Y.J Clin Pharm Ther. 2014 Aug;39(4):418-23. doi: 10.1111/jcpt.12158. Epub 2014 Mar 27. PMID: 24673513 </br>3:Development and validation of a rapid and sensitive liquid chromatography-tandem mass spectrometry method for benvitimod quantification in human plasma. Zhao L, Zhu B, Chen X, Chen G, Chen H, Li Y, Jing S, Fang Y.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Feb 15;885-886:160-5. doi: 10.1016/j.jchromb.2011.12.026. Epub 2012 Jan 9. Erratum in: J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Apr 1;891-892:113. PMID: 22281235 |
