For research use only. Not for therapeutic Use.
Benzoquinoquinoxaline (BQQ) is a heterocyclic compound with an aminoalkyl side chain. Benzoquinoquinoxaline preferentially binds to DNA triplex structures, intercalates between the bases, thus, stabilising the triplex conformation. Conjugation of Benzoquinoquinoxaline to 1,10-phenanthroline specifically binds and cleaves double strand DNA at the site of formation of a triplex structure[1].
| Catalog Number | I042921 |
| CAS Number | 207671-99-6 |
| Synonyms | N’-(19-methoxy-2,10,13-triazapentacyclo[12.8.0.03,12.04,9.017,22]docosa-1(14),2,4,6,8,10,12,15,17(22),18,20-undecaen-11-yl)propane-1,3-diamine |
| Molecular Formula | C23H21N5O |
| Purity | ≥95% |
| InChI | InChI=1S/C23H21N5O/c1-29-15-8-9-16-14(13-15)7-10-19-20(16)28-21-17-5-2-3-6-18(17)27-23(22(21)26-19)25-12-4-11-24/h2-3,5-10,13H,4,11-12,24H2,1H3,(H,25,27) |
| InChIKey | VLYNNEGUOHUAER-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=C1)C3=C(C=C2)N=C4C(=N3)C5=CC=CC=C5N=C4NCCCN |
| Reference | [1]. Umek T, et al. Oligonucleotide Binding to Non-B-DNA in MYC. Molecules. 2019 Mar 12;24(5):1000. |
