Benzothiohydrazide

• CAT Number: I017559
• CAS Number: 20605-40-7
• Molecular Formula: C₇H₈N₂S
• Molecular Weight: 152.22
• Purity: ≥95%
• Target: Bacterial
• Storage: Store at -20°C
• IUPAC Name: benzenecarbothiohydrazide
• InChI: InChI=1S/C7H8N2S/c8-9-7(10)6-4-2-1-3-5-6/h1-5H,8H2,(H,9,10)
• InChIKey: PNALOBAQBMAHBZ-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C(=S)NN

Benzothiohydrazide（Cat No.:I017559） is an analog of the anti-tuberculosis drug Isoniazid and exhibits anti-tuberculosis activity. It has been shown to have MICs (minimum inhibitory concentrations) of 132 μM and 264 μM against M. tuberculosis wild-type and clinical mutants (IC1 and IC2), respectively. These findings suggest that benzothiohydrazide possesses potential as an anti-tuberculosis agent. Its activity against both wild-type and mutant strains of M. tuberculosis indicates its potential effectiveness in combating tuberculosis infections, including drug-resistant strains.

Reference

[1]. J. Laborde, et al. Synthesis, oxidation potential and anti–mycobacterial activity of isoniazid and analogues: insights into the molecular isoniazid activation mechanism. ChemistrySelect, 1(2), 172–179.