For research use only. Not for therapeutic Use.
Benzoylhypaconine (Benzoylhypacoitine) is a monoester Aconitum alkaloid, is the main pharmacologic and toxic component[1].
Aconitum alkaloids have narrow therapeutic indices. Their potential toxicity, which is caused by hyperpolarization and activation of voltage-dependent sodium and calcium channels, can result in fatal cardiac poisoning and neurotoxicity[1].
| Catalog Number | I004383 |
| CAS Number | 63238-66-4 |
| Synonyms | [(2R,3R,4R,5R,6S,7S,8R,13S,16S,17R,18R)-5,7,8-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate |
| Molecular Formula | C31H43NO9 |
| Purity | ≥95% |
| InChI | InChI=1S/C31H43NO9/c1-32-14-28(15-37-2)12-11-18(38-3)30-17-13-29(35)25(41-27(34)16-9-7-6-8-10-16)19(17)31(36,24(33)26(29)40-5)20(23(30)32)21(39-4)22(28)30/h6-10,17-26,33,35-36H,11-15H2,1-5H3/t17-,18+,19-,20?,21+,22-,23?,24+,25-,26+,28+,29-,30?,31-/m1/s1 |
| InChIKey | MDFCJNFOINXVSU-LUOWNJJZSA-N |
| SMILES | CN1CC2(CCC(C34C2C(C(C31)C5(C6C4CC(C6OC(=O)C7=CC=CC=C7)(C(C5O)OC)O)O)OC)OC)COC |
| Reference | [1]. Song S, et al. Simultaneous quantification and pharmacokinetics of alkaloids in Herba Ephedrae-Radix Aconiti Lateralis extracts. J Anal Toxicol. 2015 Jan-Feb;39(1):58-68. [2]. Zhang YY, Yao YD, Cheng QQ, Huang YF, Zhou H. Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-Induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates [published online ahead of print, 2022 |
