For research use only. Not for therapeutic Use.
Benzyl-PEG2-amine (Cat No.: I014157) is a compound used in bioconjugation and drug delivery applications. It consists of a polyethylene glycol (PEG) chain with two ethylene glycol units, attached to a benzyl group and an amine functional group. The PEG chain enhances the compound’s solubility, stability, and bioavailability, while the amine group allows for further functionalization or conjugation with other molecules, such as drugs or targeting ligands. Benzyl-PEG2-amine is studied for its potential in improving the delivery of therapeutics, particularly in cancer treatment and gene therapy.
| CAS Number | 1268135-96-1 |
| Synonyms | Benzyl-PEG2-amine;2-(2-(benzyloxy)ethoxy)ethan-1-amine |
| Molecular Formula | C11H17NO2 |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C11H17NO2/c12-6-7-13-8-9-14-10-11-4-2-1-3-5-11/h1-5H,6-10,12H2 |
| InChIKey | SQXOAFKQZRVRTF-UHFFFAOYSA-N |
| SMILES | NCCOCCOCC1=CC=CC=C1 |
| Reference | </br>1: Kim HJ, Miyata K, Nomoto T, Zheng M, Kim A, Liu X, Cabral H, Christie RJ, Nishiyama N, Kataoka K. siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials. 2014 May;35(15):4548-56. doi: 10.1016/j.biomaterials.2014.02.016. Epub 2014 Mar 6. PubMed PMID: 24613051.</br>2: Acton AL, Fante C, Flatley B, Burattini S, Hamley IW, Wang Z, Greco F, Hayes W. Janus PEG-based dendrimers for use in combination therapy: controlled multi-drug loading and sequential release. Biomacromolecules. 2013 Feb 11;14(2):564-74. doi: 10.1021/bm301881h. Epub 2013 Jan 18. PubMed PMID: 23305104.</br>3: Mueller C, Capelle MA, Seyrek E, Martel S, Carrupt PA, Arvinte T, Borchard G. Noncovalent PEGylation: different effects of dansyl-, L-tryptophan-, phenylbutylamino-, benzyl- and cholesteryl-PEGs on the aggregation of salmon calcitonin and lysozyme. J Pharm Sci. 2012 Jun;101(6):1995-2008. doi: 10.1002/jps.23110. Epub 2012 Mar 23. PubMed PMID: 22447529. </br> </br> |
